Association between fractional flow reserve and CMR-derived exercise capacity

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): NMRC Open-Fund Young Individual Research Grant, Singapore. Background In-scanner exercise stress cardiac magnetic resonance (ExCMR) imaging using supine cycling ergometer offers assessment perfusion defects, inducible regional wall motion abnormalities, viability and capacity in a single examination (EMPIRE Trial). Aim We aim to investigate the role CMR-derived assess physiological stenosis severity, measured by invasive fractional flow reserve (FFR). Methods 107 patients (60±8 years, 80 males) with suspected coronary artery disease (CAD) underwent ExCMR (Siemens 1.5T) angiogram FFR measurement (PressureWireTMX Guidewire Abbott Laboratories) followed previously published trial protocol [1]. Exercise was derived as age- sex-specific percentile peak index, according reference range established [2]. Results remains only predictor values (beta 0.005, P<0.001) backward multivariate regression clinical variables (age, sex, BMI, presence hyperlipidema, blood pressure, diabetes mellitus) quantitative CMR parameters (LV mass, extracellular volume, LV stroke volume at rest capacity). Patients haemodynamically significant CAD (FFR<0.8) had significantly lower (median 14 [IQR 4–20] vs 5 1–10] Conclusion In addition abnormalities detect disease, predicts severity.